Aminoglycosides for Treatment of Bacteremia Due to Carbapenem-Resistant Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Aminoglycosides for Treatment of Bacteremia Due to Carbapenem-Resistant Klebsiella pneumoniae

Published:2016-05 Issue:5 Volume:60 Page:3187-3192
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Shields Ryan K.¹²,Clancy Cornelius J.¹²³,Press Ellen G.¹,Nguyen M. Hong¹²

Affiliation:

1. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

3. VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA

Abstract

ABSTRACT Aminoglycoside treatment of carbapenem-resistant (CR) Klebsiella pneumoniae bacteremia was associated with a 70% rate (23/33) of 30-day survival. Successful treatment was associated with sources of bacteremia amenable to reliable aminoglycoside pharmacokinetics ( P = 0.037), acute physiology and chronic health evaluation II (APACHE II) scores of <20 ( P = 0.16), and nonfatal underlying diseases ( P = 0.015). Success rates were 78% and 100% if ≥2 and all 3 factors were present, respectively. Clinicians may consider the use of aminoglycosides against CR K. pneumoniae bacteremia if strains are susceptible and the sources of infection are amenable to reliable pharmacokinetics.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02638-15

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