Systems-Wide Dissection of Organic Acid Assimilation in Pseudomonas aeruginosa Reveals a Novel Path To Underground Metabolism

Author:

Dolan Stephen K.123ORCID,Wijaya Andre4,Kohlstedt Michael5,Gläser Lars5,Brear Paul6,Silva-Rocha Rafael7ORCID,Wittmann Christoph5ORCID,Welch Martin6ORCID

Affiliation:

1. School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA

2. Emory–Children’s Cystic Fibrosis Center, Atlanta, Georgia, USA

3. Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA

4. Centre for Targeted Protein Degradation, University of Dundee, Dundee, Scotland, United Kingdom

5. Institute of Systems Biotechnology, Saarland University, Saarbrücken, Germany

6. Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

7. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil

Abstract

Pseudomonas aeruginosa is an opportunistic human pathogen that, due to its unrivalled resistance to antibiotics, ubiquity in the built environment, and aggressiveness in infection scenarios, has acquired the somewhat dubious accolade of being designated a “critical priority pathogen” by the WHO. In this work, we uncover the pathways and mechanisms used by P. aeruginosa to grow on a substrate that is abundant at many infection sites: propionate.

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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