APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia-Reference-Cited by-同舟云学术

APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia

Published:2019-02 Issue:2 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Viriyakosol Suganya¹,Kapoor Mili²,Okamoto Sharon³,Covel Jonathan²,Soltow Quinlyn A.²,Trzoss Michael²,Shaw Karen Joy²,Fierer Joshua¹²

Affiliation:

1. VA Healthcare, San Diego, California, USA

2. Amplyx Pharmaceuticals, San Diego, California, USA

3. Division of Infectious Diseases, Department of Medicine, UC San Diego School of Medicine, San Diego, California, USA

Abstract

Coccidioidomycosis is a systemic fungal infection caused by the inhalation of the arthroconidia of either of two closely related dimorphic fungi, Coccidioides immitis and C. posadasii , that are endemic in the southwestern United States and other areas in the Western Hemisphere. Chronic cavitary pulmonary infections and extrapulmonary sites of infection are very difficult to treat and often require lifelong azole therapy.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01715-18

Reference39 articles.

1. Coccidioidomycosis—A Fungal Disease of the Americas

2. Molecular and phenotypic description ofCoccidioides posadasiisp. nov., previously recognized as the non-California population ofCoccidioides immitis

3. The endozoan, small-mammal reservoir hypothesis and the life cycle of Coccidioides species;Taylor JW;Med Mycol