In vitro manogepix susceptibility testing of South African Emergomyces africanus, Emergomyces pasteurianus , and Blastomyces emzantsi clinical isolates

Abstract

ABSTRACT We performed in vitro antifungal susceptibility testing of manogepix against the yeast phase of 78 Emergomyces africanus , 2 Emergomyces pasteurianus, and 5 Blastomyces emzantsi isolates using a reference broth microdilution method following Clinical and Laboratory Standards Institute recommendations. All three pathogens had low minimum inhibitory concentrations ranging from <0.0005 to 0.008 mg/L. Manogepix should be investigated in animal models and potentially in future human clinical trials for endemic mycoses.