Author:
Johnson James R.,Porter Stephen B.,Thuras Paul,Johnson Timothy J.,Price Lance B.,Tchesnokova Veronika,Sokurenko Evgeni V.
Abstract
ABSTRACTMinimum bactericidal concentrations (MBCs) for ciprofloxacin were significantly higher among 41 members of theH30 subclone withinEscherichia colisequence type 131 than among 48 other fluoroquinolone-resistantE. coliisolates. This MBC difference, which was not explained by ciprofloxacin MICs,gyrA,parC, andparEmutations, the presence ofaac(6′)-Ib-cr, or organic solvent tolerance (a surrogate for efflux pump activity), conceivably could have promoted the pandemic emergence of theH30 sequence type 131 subclone.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
11 articles.
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