Limited Multidrug Resistance Efflux Pump Overexpression among Multidrug-Resistant Escherichia coli Strains of ST131-Reference-Cited by-同舟云学术

Limited Multidrug Resistance Efflux Pump Overexpression among Multidrug-Resistant Escherichia coli Strains of ST131

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Camp Johannes¹^ORCID,Schuster Sabine¹^ORCID,Vavra Martina¹,Schweigger Tobias¹,Rossen John W. A.²³⁴,Reuter Sandra⁵,Kern Winfried V.¹

Affiliation:

1. Division of Infectious Diseases, Department of Medicine II, Medical Centre and Faculty of Medicine, University of Freiburg, Freiburg, Germany

2. Department of Medical Microbiology and Infection Prevention, Faculty of Medical Sciences, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

3. Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA

4. IDbyDNA Inc., Salt Lake City, Utah, USA

5. Institute for Infection Prevention and Hospital Epidemiology, Center for Microbiology, Virology and Hygiene, Medical Centre and Faculty of Medicine, University of Freiburg, Freiburg, Germany

Abstract

Gram-negative bacteria partly rely on efflux pumps to facilitate growth under stressful conditions and to increase resistance to a wide variety of commonly used drugs. In recent years, Escherichia coli sequence type 131 (ST131) has emerged as a major cause of extraintestinal infection frequently exhibiting a multidrug resistance (MDR) phenotype.

Funder

Innovative Medicines Initiative

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01735-20

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2. The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

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