Affiliation:
1. Biotechnology Division, Regional Research Laboratory, Jammu Tawi 180001, India
Abstract
ABSTRACT
Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for
Staphylococcus aureus
, including methicillin-resistant
S. aureus
. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIP
r
-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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