Clink, a Nanovirus-Encoded Protein, Binds both pRB and SKP1-Reference-Cited by-同舟云学术

Clink, a Nanovirus-Encoded Protein, Binds both pRB and SKP1

Published:2000-04 Issue:7 Volume:74 Page:2967-2972
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Aronson Marie N.¹,Meyer Alain D.¹,Györgyey Jànos¹,Katul Lina²,Vetten H. Josef²,Gronenborn Bruno¹,Timchenko Tatiana¹

Affiliation:

1. Institut des Sciences Végétales, CNRS, 91198 Gif sur Yvette, France,1 and

2. Biologische Bundesanstalt für Land und Forstwirtschaft, Institut für Pflanzenvirologie, Mikrobiologie und Biologische Sicherheit, D-38104 Braunschweig, Germany2

Abstract

ABSTRACT Clink, a 20-kDa protein of faba bean necrotic yellows virus, a single-stranded DNA plant virus, interacts with pRB family members and a SKP1 homologue from Medicago sativa . An LxCxE motif and an F-box of Clink mediate the interactions with the respective proteins. The capacity of Clink to bind pRB correlates with its ability to stimulate viral replication. Interaction of a single protein with the cell cycle regulator pRB and SKP1, a constituent of the ubiquitin-protein turnover pathway, appears to be a novel feature. Hence, Clink may represent a new class of viral cell cycle modulators.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.7.2967-2972.2000

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