Antiviral Activity and Induction of Interferon-Like Substance by Quinacrine and Acranil

Author:

Gláz E. T.1,Szolgay Erika1,Stöger Ivana1,Tálas Margarita1

Affiliation:

1. Department of Pharmacology, Semmelweis Medical University, and Microbiological Research Group of the Hungarian Academy of Sciences, Budapest, Hungary

Abstract

Several drugs with certain structural similarities (tricyclic ring system with dialkylaminoalkyl side chains) to tilorone, a potent interferon inducer, were screened for antiviral activity in vivo. Two acridine drugs, Acranil and quinacrine, were found to be effective, the former being almost as protective as tilorone and the latter less so. Both agents induced an interferon-like substance which could be detected in the serum of treated mice. The concentration of the inhibitory factor in the serum was highest after exposure to tilorone, followed in turn by Acranil and quinacrine, based on the administration of equal weights of drugs. Both tilorone and Acranil induced lower levels of circulating interferon-like substance in Balb/c mice than in other strains of mice. The serum factor induced by Acranil was shown to be stable at pH 2.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference16 articles.

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3. Influence of animal genotype and age on the amount of circulating interferon induced by Newcastle disease virus;De Maeyer E.;J. Gen. Virol.,1968

4. Studies on the induction of mutations in poliovirus by proflavin;Dulbecco R.;Virology,1958

5. In vitro and in vivo antiviral action of an interferon-like substance induced by Toxoplasma gondii;Freshman M. M.;Proc. Soc. Exp. Biol. Med.,1966

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