Author:
Lane Thomas R.,Comer Jason E.,Freiberg Alexander N.,Madrid Peter B.,Ekins Sean
Abstract
ABSTRACTQuinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar)in vitroinhibitor. In the current study, quinacrine 25 mg/kg was shown to protect 70% of mice (statistically significant) from a lethal challenge with mouse-adapted EBOV with once-daily intraperitoneal dosing for 8 days.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
HHS | NIH | National Center for Advancing Translational Sciences (NCATS)
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
28 articles.
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