Link between Interleukin-23 and Anti-CD4 Autoantibody Production in Antiretroviral-Treated HIV-Infected Individuals-Reference-Cited by-同舟云学术

Link between Interleukin-23 and Anti-CD4 Autoantibody Production in Antiretroviral-Treated HIV-Infected Individuals

Published:2021-05-10 Issue:11 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Luo Zhenwu¹,Li Min¹,Mi Fuli²,Meng Zhefeng³,Du Guoqiang⁴,Martin Lisa⁵,Liu Hui⁶,Jin Ping⁶,Stroncek David⁶,Heath Sonya L.⁷,Jiang Wei¹⁵^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA

2. Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University, Shandong, China

3. Department of Gastroenterology, Oncology Bioinformatics Center, Minhang Hospital, Fudan University, Shanghai, China

4. Shandong Provincial Hospital Pediatric Surgery, Shandong, China

5. Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA

6. Cell Processing Section, Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, Maryland, USA

7. Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA

Abstract

In our published studies, we determined that pathological anti-CD4 IgGs from immunologic nonresponders on virally suppressive ART (CD4 cell counts < 350 cells/μl) mediated CD4 + T cell death via antibody-mediated cytotoxicity (ADCC), which plays a role in poor CD4 + T cell recovery from ART. Up to 25% of HIV-infected individuals are nonresponders and demonstrate increased morbidity and mortality.

Funder

HHS | NIH | NIH Clinical Center

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00271-21

Reference53 articles.

1. Immune reconstitution after a decade of combined antiretroviral therapies for human immunodeficiency virus

2. Incomplete Peripheral CD4+Cell Count Restoration in HIV‐Infected Patients Receiving Long‐Term Antiretroviral Treatment

3. Immunological recovery and antiretroviral therapy in HIV-1 infection

4. CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection

5. Risk of clinical progression among patients with immunological nonresponse despite virological suppression after combination antiretroviral treatment

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. COVID‐19 mRNA vaccine, but not a viral vector‐based vaccine, promotes neutralizing anti‐type I interferon autoantibody production in a small group of healthy individuals;Journal of Medical Virology;2023-10

2. Impacts of plasma microbial lipopolysaccharide translocation on B cell perturbations and anti-CD4 autoantibody production in people with HIV on suppressive antiretroviral therapy;Cell & Bioscience;2023-05-03

3. Infectious diseases, autoantibodies, and autoimmunity;Journal of Autoimmunity;2022-12

4. Elevated Cerebrospinal Fluid Anti-CD4 Autoantibody Levels in HIV Associate with Neuroinflammation;Microbiology Spectrum;2022-02-23