Elevated Cerebrospinal Fluid Anti-CD4 Autoantibody Levels in HIV Associate with Neuroinflammation

Author:

Cheng Da12,Luo Zhenwu1,Fu Xiaoyu12,Stephenson Sophie3,Di Germanio Clara45,Norris Philip J.45,Fuchs Dietmar6,Ndhlovu Lishomwa C.7,Li Quan-zhen8,Zetterberg Henrik910111213,Gisslen Magnus1415,Price Richard W.3,Peng Shifang216,Jiang Wei117ORCID

Affiliation:

1. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA

2. Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha, China

3. Department of Neurology, University of California San Francisco, San Francisco General Hospital, San Francisco, California, USA

4. Vitalant Research Institute, San Francisco, California, USA

5. Department of Laboratory Medicine, University of California, San Francisco, California, USA

6. Institut für Biologische Chemie, Biozentrum, Medizinische Universität Innsbruck, Innrain, Innsbruck, Austria

7. Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA

8. Department of Immunology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA

9. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

10. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

11. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom

12. UK Dementia Research Institute at UCL, London, United Kingdom

13. Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China

14. Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

15. Region Västra Götaland, Sahlgrenska University Hospital, Department of Infectious Diseases, Gothenburg, Sweden

16. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University, Changsha, China

17. Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA

Abstract

This study reports that an autoantibody presents in the CNS of HIV patients and that its levels in the CSF correlate with some markers of neuroinflammation.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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