Affiliation:
1. Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
Abstract
ABSTRACT
The triple-base-pair 16S rDNA mutation AGA
926-928
→TTC mediates high-level tetracycline resistance in
Helicobacter pylori
. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant
H. pylori
isolates.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
59 articles.
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