Explaining the Bias in the 23S rRNA Gene Mutations Associated with Clarithromycin Resistance in Clinical Isolates of Helicobacter pylori-Reference-Cited by-同舟云学术

Explaining the Bias in the 23S rRNA Gene Mutations Associated with Clarithromycin Resistance in Clinical Isolates of Helicobacter pylori

Published:1998-10 Issue:10 Volume:42 Page:2749-2751
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Debets-Ossenkopp Y. J.¹,Brinkman A. B.¹,Kuipers E. J.²,Vandenbroucke-Grauls C. M. J. E.¹,Kusters J. G.¹

Affiliation:

1. Departments of Clinical Microbiology and Infection Control1 and

2. Gastroenterology,2 University Hospital Vrije Universiteit, Amsterdam, The Netherlands

Abstract

ABSTRACT A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H. pylori isolates are the mutations from A-2142 to G and A-2143 to G in the 23S rRNA gene. The bias in the 23S rRNA gene mutations conferring clarithromycin resistance may result from the higher MIC, stability of resistance, and growth rate found for the strains with the above-mentioned mutations.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.10.2749

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