Evidence for the Mycobacterial Mce4 Transporter Being a Multiprotein Complex-Reference-Cited by-同舟云学术

Evidence for the Mycobacterial Mce4 Transporter Being a Multiprotein Complex

Published:2021-04-21 Issue:10 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Rank Laura¹,Herring Laura E.²³,Braunstein Miriam¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. UNC Michael Hooker Proteomics Core Facility, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

3. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

How lipids travel between membranes of diderm bacteria is a challenging mechanistic question because lipids, which are hydrophobic molecules, must traverse a hydrophilic periplasm. This question is even more complex for mycobacteria, which have a unique cell envelope that is highly impermeable to molecules.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00685-20

Reference63 articles.

1. Bacterial membrane lipids: diversity in structures and pathways

2. Cholesterol and fatty acids grease the wheels of Mycobacterium tuberculosis pathogenesis