Line Immunoassay for Confirmation and Discrimination of Human T-Cell Lymphotropic Virus Infections in Inconclusive Western Blot Serum Samples from Brazil-Reference-Cited by-同舟云学术

Line Immunoassay for Confirmation and Discrimination of Human T-Cell Lymphotropic Virus Infections in Inconclusive Western Blot Serum Samples from Brazil

Published:2019-12-23 Issue:1 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Campos Karoline R.¹,Santos Fred L. N.²^ORCID,da Silva Brito Vanessa³,Gonçalves Noilson L. S.²³,Araujo Thessika H. A.³,Galvão-Castro Bernardo²³,Caterino-de-Araujo Adele¹

Affiliation:

1. Immunology Department, Adolfo Lutz Institute (IAL), São Paulo, São Paulo, Brazil

2. Advanced Laboratory of Public Health, Gonçalo Moniz Institute (IGM), FIOCRUZ-BA, Salvador, Bahia, Brazil

3. Integrated and Multidisciplinary HTLV Center, Bahiana School of Medicine and Public Health (EBMSP), Salvador, Bahia, Brazil

Abstract

Difficulties in confirming and discriminating human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 infections by serological Western blot (WB) assays (HTLV Blot 2.4; MP Biomedicals) have been reported in Brazil, mainly in HIV/AIDS patients, with a large number of WB-indeterminate and WB-positive but HTLV-untypeable results. Nonetheless, a line immunoassay (LIA) (INNO-LIA HTLV-I/II; Fujirebio) provided enhanced specificity and sensitivity for confirming HTLV-1/2 infections.

Funder

Fundação Nacional para o Desenvolvimento do Ensino Superior

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Fundação de Amparo à Pesquisa do Estado da Bahia

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01384-19