The Human Nose Organoid Respiratory Virus Model: an <i>Ex Vivo</i> Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics-Reference-Cited by-同舟云学术

The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rajan Anubama¹,Weaver Ashley Morgan¹,Aloisio Gina Marie¹,Jelinski Joseph¹,Johnson Hannah L.²³,Venable Susan F.⁴,McBride Trevor¹,Aideyan Letisha¹,Piedra Felipe-Andrés¹,Ye Xunyan¹,Melicoff-Portillo Ernestina⁵,Yerramilli Malli Rama Kanthi¹,Zeng Xi-Lei¹,Mancini Michael A.²³,Stossi Fabio²³,Maresso Anthony W.¹,Kotkar Shalaka A.⁶,Estes Mary K.¹⁷⁸^ORCID,Blutt Sarah¹,Avadhanula Vasanthi¹,Piedra Pedro A.¹⁹^ORCID

Affiliation:

1. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

2. Advanced Technology Cores, Baylor College of Medicine, Houston, Texas, USA

3. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

4. Department of Pathology, Baylor College of Medicine, Houston, Texas, USA

5. Department of Pediatrics, Pulmonary Medicine Service, Baylor College of Medicine, Houston, Texas, USA

6. Environmental Safety Department, Baylor College of Medicine, Houston, Texas, USA

7. Department of Medicine, Section of Infectious Diseases and Gastroenterology, Baylor College of Medicine, Houston, Texas, USA

8. Department of Medicine, Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas, USA

9. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA

Abstract

Preclinical models that recapitulate aspects of human airway disease are essential for the advancement of novel therapeutics and vaccines. Here, we report a versatile airway organoid model, the human nose organoid (HNO), that recapitulates the complex interactions between the host and virus.

Funder

HHS | U.S. Public Health Service

Cancer Prevention and Research Institute of Texas

HHS | NIH | NIH Clinical Center

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03511-21

Reference60 articles.