COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging-Reference-Cited by-同舟云学术

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COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging

Published:2023-11 Issue:5 Volume:69 Page:592-595
ISSN:1044-1549
Container-title:American Journal of Respiratory Cell and Molecular Biology
language:en
Short-container-title:Am J Respir Cell Mol Biol

Author:

Vijaykumar Kadambari¹²,Leung Hui Min³⁴,Barrios Amilcar³⁴,Fernandez-Petty Courtney M.²,Solomon George M.¹²,Hathorne Heather Y.²,Wade Justin D.²,Monroe Kathryn²,Slaten Katie Brand²,Li Qian²,Leal Sixto M.¹,Moates Derek B.¹,Pierce Hannah M.¹,Olson Kristian R.³⁴⁵,Currier Paul⁵,Foster Sam⁵,Marsden Doug⁵⁶,Tearney Guillermo J.³⁴,Rowe Steven M.¹²^ORCID

Affiliation:

1. University of Alabama at BirminghamBirmingham, Alabama

2. Gregory Fleming James Cystic Fibrosis Research CenterBirmingham, Alabama

3. Massachusetts General HospitalBoston, Massachusetts

4. Harvard Medical SchoolBoston, Massachusetts

5. Healthcare Innovation PartnersBoston, Massachusetts

6. ELEVEN, LLCBoston, Massachusetts

Funder

NIH

Mike and Sue Hazard Family and the Remondi Family Foundations

University of Alabama at Birmingham

Cystic Fibrosis Foundation

Publisher

American Thoracic Society

Subject

Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology

Link

https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2023-0177LE

Reference21 articles.

1. Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19

2. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

3. SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

4. SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

5. Propagation of respiratory viruses in human airway epithelia reveals persistent virus-specific signatures

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1. Longitudinal improvements in clinical and functional outcomes following initiation of elexacaftor/tezacaftor/ivacaftor in patients with cystic fibrosis;Heliyon;2024-04

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