Sequence of pNL194, a 79.3-Kilobase IncN Plasmid Carrying the bla VIM-1 Metallo-β-Lactamase Gene in Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Sequence of pNL194, a 79.3-Kilobase IncN Plasmid Carrying the bla VIM-1 Metallo-β-Lactamase Gene in Klebsiella pneumoniae

Published:2010-10 Issue:10 Volume:54 Page:4497-4502
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Miriagou V.¹,Papagiannitsis C. C.¹,Kotsakis S. D.¹,Loli A.¹,Tzelepi E.¹,Legakis N. J.²,Tzouvelekis L. S.³

Affiliation:

1. Laboratory of Bacteriology, Hellenic Pasteur Institute

2. Department of Biopathology, Evgenidion General Hospital

3. Department of Microbiology, Medical School, University of Athens, Athens, Greece

Abstract

ABSTRACT The nucleotide sequence of pNL194, a VIM-1-encoding plasmid, is described in this study. pNL194 (79,307 bp) comprised an IncN-characteristic segment (38,940 bp) and a mosaic structure (40,367 bp) including bla VIM-1 , aacA7 , aadA1 , aadA2 , dfrA1 , dfrA12 , aphA1 , strA , strB , and sul1 . Tn 1000 or Tn 5501 insertion within fipA probably facilitated recruitment of additional mobile elements carrying resistance genes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00665-10

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