Bacteriophage T7 RNA polymerase travels far ahead of ribosomes in vivo-Reference-Cited by-同舟云学术

Bacteriophage T7 RNA polymerase travels far ahead of ribosomes in vivo

Published:1992-01 Issue:2 Volume:174 Page:619-622
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Iost I¹,Guillerez J¹,Dreyfus M¹

Affiliation:

1. Laboratoire de Génétique Moléculaire (Centre National de la Recherche Scientifique D1302), Ecole Normale Supérieure, Paris, France.

Abstract

We show that in Escherichia coli at 32 degrees C, the T7 RNA polymerase travels over the lacZ gene about eightfold faster than ribosomes travel over the corresponding mRNA. We discuss how the T7 phage might exploit this high rate in its growth optimization strategy and how it obviates the possible drawbacks of uncoupling transcription from translation.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.174.2.619-622.1992

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