Structure of the Streptococcus pyogenes NAD + Glycohydrolase Translocation Domain and Its Essential Role in Toxin Binding to Oropharyngeal Keratinocytes-Reference-Cited by-同舟云学术

Structure of the Streptococcus pyogenes NAD + Glycohydrolase Translocation Domain and Its Essential Role in Toxin Binding to Oropharyngeal Keratinocytes

Published:2022-01-18 Issue:1 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Velarde Jorge J.¹,Piai Alessandro²,Lichtenstein Ian J.¹,Lynskey Nicola N.¹,Chou James J.²,Wessels Michael R.¹

Affiliation:

1. Division of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

Abstract

NADase and streptolysin O (SLO) are secreted toxins important for pathogenesis of group A Streptococcus , the agent of strep throat and severe invasive infections. The two toxins interact in solution and mutually enhance cytotoxic activity.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00366-21

Reference57 articles.

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2. A molecular trigger for intercontinental epidemics of group A Streptococcus

3. Evolutionary Origin and Emergence of a Highly Successful Clone of Serotype M1 Group AStreptococcusInvolved Multiple Horizontal Gene Transfer Events