Characterization of Chlamydia pneumoniae Persistence in HEp-2 Cells Treated with Gamma Interferon-Reference-Cited by-同舟云学术

Characterization of Chlamydia pneumoniae Persistence in HEp-2 Cells Treated with Gamma Interferon

Published:2001-12 Issue:12 Volume:69 Page:7927-7932
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Pantoja Laura G.¹²,Miller Richard D.²,Ramirez Julio A.¹,Molestina Robert E.¹,Summersgill James T.¹²

Affiliation:

1. Division of Infectious Diseases, Department of Medicine,1 and

2. Department of Microbiology and Immunology,2 University of Louisville School of Medicine, Louisville, Kentucky 40292

Abstract

ABSTRACT Infection with Chlamydia pneumoniae has been implicated as a potential risk factor for atherosclerosis. This study demonstrated the effects of gamma interferon (IFN-γ)-mediated indoleamine 2,3-dioxygenase activity on C. pneumoniae persistence in HEp-2 cells, inclusion morphology, and ultrastructure. C. pneumoniae replication showed a dose-dependent decrease when treated with increasing concentrations of IFN-γ and a phenotypic switch resulting in a decrease in typical inclusions with an increase in smaller, less-dense atypical inclusions. Ultrastructural analysis of IFN-γ-treated C. pneumoniae revealed atypical inclusions containing large reticulatate-like aberrant bodies with no evidence of redifferentiation into elementary bodies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.12.7927-7932.2001

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