Bile Salts Induce Resistance to Polymyxin in Enterohemorrhagic Escherichia coliO157:H7-Reference-Cited by-同舟云学术

Bile Salts Induce Resistance to Polymyxin in Enterohemorrhagic Escherichia coliO157:H7

Published:2011-09 Issue:17 Volume:193 Page:4509-4515
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Kus Julianne V.¹,Gebremedhin Ahferom¹,Dang Vica¹,Tran Seav-Ly¹,Serbanescu Anca¹,Foster Debora Barnett¹²

Affiliation:

1. Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada

2. Program for Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario, Canada

Abstract

ABSTRACT Many enteric bacteria use bile as an environmental cue to signal resistance and virulence gene expression. Microarray analysis of enterohemorrhagic Escherichia coli O157:H7 (EHEC) treated with bile salts revealed upregulation of genes for an efflux system ( acrAB ), a two-component signal transduction system ( basRS / pmrAB ), and lipid A modification ( arnBCADTEF and ugd ). Bile salt treatment of EHEC produced a basS - and arnT -dependent resistance to polymyxin.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00200-11

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