The Role of the Gallbladder, the Intestinal Barrier and the Gut Microbiota in the Development of Food Allergies and Other Disorders

Author:

Abril Ana G.ORCID,Villa Tomás G.ORCID,Sánchez-Pérez Ángeles,Notario VicenteORCID,Carrera MónicaORCID

Abstract

The microbiota present in the gastrointestinal tract is involved in the development or prevention of food allergies and autoimmune disorders; these bacteria can enter the gallbladder and, depending on the species involved, can either be benign or cause significant diseases. Occlusion of the gallbladder, usually due to the presence of calculi blocking the bile duct, facilitates microbial infection and inflammation, which can be serious enough to require life-saving surgery. In addition, the biliary salts are secreted into the intestine and can affect the gut microbiota. The interaction between the gut microbiota, pathogenic organisms, and the human immune system can create intestinal dysbiosis, generating a variety of syndromes including the development of food allergies and autoimmune disorders. The intestinal microbiota can aggravate certain food allergies, which become severe when the integrity of the intestinal barrier is affected, allowing bacteria, or their metabolites, to cross the intestinal barrier and invade the bloodstream, affecting distal body organs. This article deals with health conditions and severe diseases that are either influenced by the gut flora or caused by gallbladder obstruction and inflammation, as well as putative treatments for those illnesses.

Funder

Spanish Ministry of Universities with European Union’s NextGeneration EU funds

Xunta de Galicia and the European Union

Spanish Ministry of Economy and Competitivity

European Regional Development Fund

GAIN-Xunta de Galicia

Spanish AEI/EU-FEDER

Ministry of Science and Innovation

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference228 articles.

1. Villa, T., and Vinas, M. (2016). New Weapons to Control Bacterial Growth, Springer.

2. Villa, T.G., and de Miguel Bouzas, T. (2016). Developmental Biology in Prokaryotes and Lower Eukaryotes, Springer.

3. Villa, T., and Vinas, M. (2016). New Weapons to Control Bacterial Growth, Springer.

4. In vitro ecology: A discovery engine for microbiome therapies;Nat. Rev. Gastroenterol. Hepatol.,2020

5. Introduction to the human gut microbiota;Biochem. J.,2017

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3