Induction of alpha interferon by human immunodeficiency virus type 1 in human monocyte-macrophage cultures-Reference-Cited by-同舟云学术

Induction of alpha interferon by human immunodeficiency virus type 1 in human monocyte-macrophage cultures

Published:1991-11 Issue:11 Volume:65 Page:6362-6364
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Szebeni J¹,Dieffenbach C¹,Wahl S M¹,Venkateshan C N¹,Yeh A¹,Popovic M¹,Gartner S¹,Wahl L M¹,Peterfy M¹,Friedman R M¹

Affiliation:

1. National Cancer Institute, Bethesda, Maryland 20892.

Abstract

The induction of interferon (IFN) by human immunodeficiency virus type 1 (HIV-1) in primary, nonstimulated monocyte-macrophage cultures was studied. HIV-1 infection, as confirmed by p24 antigen levels in the cell supernatant, led to the production of alpha interferon (IFN-alpha) over 7 to 21 days following infection. In two of seven experiments, the IFN detected was acid labile. Coupled reverse transcription-polymerase chain reaction analysis confirmed the induction of IFN-alpha mRNA in cells of HIV-1-infected cultures.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.65.11.6362-6364.1991

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