Mucosal Infection with Unmasked Candida albicans Cells Impacts Disease Progression in a Host Niche-Specific Manner-Reference-Cited by-同舟云学术

Mucosal Infection with Unmasked Candida albicans Cells Impacts Disease Progression in a Host Niche-Specific Manner

Published:2022-12-15 Issue:12 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Wagner Andrew S.¹,Vogel Amanda K.²,Lumsdaine Stephen W.¹,Phillips Elise K.¹^ORCID,Willems Hubertine M. E.³,Peters Brian M.³^ORCID,Reynolds Todd B.¹^ORCID

Affiliation:

1. Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA

2. Integrated Program in Biomedical Sciences, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA

3. Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA

Abstract

Shielding the immunogenic cell wall epitope β(1, 3)-glucan under an outer layer of mannosylated glycoproteins is an essential virulence factor deployed byCandida albicansduring systemic infection. Accordingly, mutants with increased β(1, 3)-glucan exposure (unmasking) display increased immunostimulatory capabilitiesin vitroand attenuated virulence during systemic infection in mice.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00342-22

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