A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and Chinchillas-Reference-Cited by-同舟云学术

A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and Chinchillas

Published:2019-08 Issue:8 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ysebaert Carine¹,Denoël Philippe¹,Weynants Vincent¹,Bakaletz Lauren O.²,Novotny Laura A.²,Godfroid Fabrice¹,Hermand Philippe¹

Affiliation:

1. GSK, Rixensart, Belgium

2. Department of Pediatrics, The Abigail Wexner Research Institute at Nationwide Children’s Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA

Abstract

PE-PilA is a fusion protein composed of immunologically relevant parts of protein E (PE) and the majority subunit of the type IV pilus (PilA), two major antigens of nontypeable Haemophilus influenzae (NTHi). Here we report on the preclinical evaluation of PE-PilA as a vaccine antigen. The immunogenic potential of the PE and PilA within the fusion was compared with that of isolated PE and PilA antigens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00345-19

Reference50 articles.

1. Persistent Colonization byHaemophilus influenzaein Chronic Obstructive Pulmonary Disease

2. A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD

3. Potential Contribution by Nontypable Haemophilus influenzae in Protracted and Recurrent Acute Otitis Media

4. Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children

5. Microbial profiling does not differentiate between childhood recurrent acute otitis media and chronic otitis media with effusion

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