Adherence of Nontypeable Haemophilus influenzae to Cells and Substrates of the Airway Is Differentially Regulated by Individual ModA Phasevarions-Reference-Cited by-同舟云学术

Adherence of Nontypeable Haemophilus influenzae to Cells and Substrates of the Airway Is Differentially Regulated by Individual ModA Phasevarions

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Garai Preeti¹,Atack John M.²³^ORCID,Wills Brandon M.¹,Jennings Michael P.²^ORCID,Bakaletz Lauren O.⁴⁵^ORCID,Brockman Kenneth L.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

2. Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia

3. School of Environment and Science, Griffith University, Gold Coast, Queensland, Australia

4. Abigail Wexner Research Institute, Center for Microbial Pathogenesis, Nationwide Children’s Hospital, Columbus, Ohio, USA

5. College of Medicine, Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA

Abstract

Nontypeable Haemophilus influenzae (NTHi) is a predominant pathogen of the human airway that causes respiratory infections such as otitis media (OM) and exacerbations in the lungs of patients suffering from chronic obstructive pulmonary disease (COPD). Due to the lack of a licensed vaccine against NTHi and the emergence of antibiotic-resistant strains, it is extremely challenging to target NTHi for treatment.

Funder

DHAC | National Health and Medical Research Council

HHS | NIH | National Institute on Deafness and Other Communication Disorders

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04093-22

Reference63 articles.

1. Nontypeable Haemophilus influenzae (NTHi)

2. Prospects for a vaccine against otitis media