Phosphotransferase System Uptake and Metabolism of the β-Glucoside Salicin Impact Group A Streptococcal Bloodstream Survival and Soft Tissue Infection-Reference-Cited by-同舟云学术

Phosphotransferase System Uptake and Metabolism of the β-Glucoside Salicin Impact Group A Streptococcal Bloodstream Survival and Soft Tissue Infection

Published:2020-09-18 Issue:10 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Braza Rezia Era¹,Silver Aliyah B.¹,Sundar Ganesh S.¹,Davis Sarah E.¹,Razi Afrooz¹,Islam Emrul¹,Hart Meaghan¹,Zhu Jinyi¹,Le Breton Yoann¹,McIver Kevin S.¹^ORCID

Affiliation:

1. Department of Cell Biology & Molecular Genetics, Maryland Pathogen Research Institute, University of Maryland, College Park, College Park, Maryland, USA

Abstract

Streptococcus pyogenes (group A Streptococcus [GAS]), a major human-specific pathogen, relies on efficient nutrient acquisition for successful infection within its host. The phosphotransferase system (PTS) couples the import of carbohydrates with their phosphorylation prior to metabolism and has been linked to GAS pathogenesis. In a screen of an insertional mutant library of all 14 annotated PTS permease (EIIC) genes in MGAS5005, the annotated β-glucoside PTS transporter ( bglP ) was found to be crucial for GAS growth and survival in human blood and was validated in another M1T1 GAS strain, 5448.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00346-20

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