Noncoding RNA of Glutamine Synthetase I Modulates Antibiotic Production in Streptomyces coelicolor A3(2)-Reference-Cited by-同舟云学术

Noncoding RNA of Glutamine Synthetase I Modulates Antibiotic Production in Streptomyces coelicolor A3(2)

Published:2010-02-15 Issue:4 Volume:192 Page:1160-1164
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

D'Alia Davide¹,Nieselt Kay²,Steigele Stephan²,Müller Jonas²,Verburg Ilse¹,Takano Eriko¹

Affiliation:

1. Department of Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands

2. Center for Bioinformatics Tübingen, Department of Information and Cognitive Sciences, University of Tübingen, Sand 14, 72076 Tübingen, Germany

Abstract

ABSTRACT Overexpression of antisense chromosomal cis -encoded noncoding RNAss (ncRNAs) in glutamine synthetase I resulted in a decrease in growth, protein synthesis, and antibiotic production in Streptomyces coelicolor . In addition, we predicted 3,597 cis -encoded ncRNAs and validated 13 of them experimentally, including several ncRNAs that are differentially expressed in bacterial hormone-defective mutants.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.01374-09

Reference24 articles.

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