Synthetic biology approaches to actinomycete strain improvement-Reference-Cited by-同舟云学术

Synthetic biology approaches to actinomycete strain improvement

Published:2021-05 Issue:10 Volume:368 Page:
ISSN:1574-6968
Container-title:FEMS Microbiology Letters
language:en
Short-container-title:

Author:

Breitling Rainer¹,Avbelj Martina²,Bilyk Oksana¹,Carratore Francesco Del¹,Filisetti Alessandro³,Hanko Erik K R¹,Iorio Marianna⁴,Redondo Rosario Pérez⁵,Reyes Fernando⁶,Rudden Michelle⁷,Severi Emmanuele⁷,Slemc Lucija²,Schmidt Kamila¹,Whittall Dominic R¹,Donadio Stefano⁴,García Antonio Rodríguez⁵,Genilloud Olga⁶,Kosec Gregor⁸,De Lucrezia Davide³,Petković Hrvoje²,Thomas Gavin⁷,Takano Eriko¹

Affiliation:

1. Department of Chemistry, Manchester Institute of Biotechnology, Manchester Synthetic Biology Research Centre SYNBIOCHEM, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK

2. Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia

3. Explora Biotech Srl, Doulix business unit, Via Torino 107, 30133 Venice, Italy

4. Naicons srl., Viale Ortles 22/4, 20139 Milano, Italy

5. INBIOTEC Instituto de Biotecnología de León, Avenida Real 1, 24006 León, Spain

6. Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 34, Parque Tecnologico de Ciencias de la Salud, 18016 Armilla, Granada, Spain

7. Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK

8. Acies Bio d.o.o., Tehnološki Park 21, 1000, Ljubljana, Slovenia

Abstract

ABSTRACT Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

Funder

European Union

Publisher

Oxford University Press (OUP)

Subject

Genetics,Molecular Biology,Microbiology

Link

http://academic.oup.com/femsle/advance-article-pdf/doi/10.1093/femsle/fnab060/38385987/fnab060.pdf

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