Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa

Published:1997-11 Issue:11 Volume:41 Page:2540-2543
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Köhler T¹,Michea-Hamzehpour M¹,Plesiat P¹,Kahr A L¹,Pechere J C¹

Affiliation:

1. Department of Genetics and Microbiology, Centre Médical Universitaire, Geneva, Switzerland. Thilo.Kohler@medecine.unige.ch

Abstract

Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.41.11.2540

Reference21 articles.

1. Microbial selection;Bryson L.;Science,1952

2. New norfloxacin resistance gene in Pseudomonas aeruginosa PAO;Fukuda H.;Antimicrob. Agents Chemother.,1990

3. nfxC-type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa;Fukuda H.;Antimicrob. Agents Chemother.,1995

4. Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa;Hirai K.;Antimicrob. Agents Chemother.,1987

5. Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa;Jakics E. B.;Antimicrob. Agents Chemother.,1992

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