Epigenomic Landscape of Lyme Disease Spirochetes Reveals Novel Motifs-Reference-Cited by-同舟云学术

Epigenomic Landscape of Lyme Disease Spirochetes Reveals Novel Motifs

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wachter Jenny¹,Martens Craig²,Barbian Kent²,Rego Ryan O. M.³⁴^ORCID,Rosa Patricia¹

Affiliation:

1. Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

2. Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

3. Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic

4. Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic

Abstract

The principal causative agent of Lyme disease in humans in the United States is Borrelia burgdorferi , while B. burgdorferi , B. afzelii , and B. garinii , collectively members of the Borrelia burgdorferi sensu lato species complex, cause Lyme disease in Europe and Asia. Two plasmid-encoded restriction/modification systems have been shown to limit the genetic transformation of B. burgdorferi type strain B31 with foreign DNA, but little is known about the restriction/modification systems of other Lyme disease Borrelia bacteria.

Funder

Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01288-21

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