Phylogenomic Diversity Elucidates Mechanistic Insights into Lyme Borreliae-Host Association

Author:

Combs Matthew123,Marcinkiewicz Ashley L.4,Dupuis Alan P.4,Davis April D.4,Lederman Patricia4,Nowak Tristan A.45,Stout Jessica L.4,Strle Klemen45,Fingerle Volker6,Margos Gabriele6,Ciota Alexander T.45,Diuk-Wasser Maria A.1,Kolokotronis Sergios-Orestis2378ORCID,Lin Yi-Pin45ORCID

Affiliation:

1. Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York, New York, USA

2. Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, New York, USA

3. Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, New York, USA

4. Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA

5. Department of Biomedical Sciences, SUNY Albany, Albany, New York, USA

6. German National Reference Centre for Borrelia, Bavarian Health and Food Safety Authority, Oberschleissheim, Germany

7. Division of Infectious Diseases, Department of Medicine, College of Medicine, SUNY Downstate Health Sciences University, Brooklyn, New York, USA

8. Department of Cell Biology, College of Medicine, SUNY Downstate Health Sciences University, Brooklyn, New York, USA

Abstract

Host association is the phenotype that is commonly found in many pathogens that preferential survive in particular hosts. The Lyme disease (LD)-causing agent, B. burgdorferi ( Bb ), is an ideal model to study host association, as Bb is mainly maintained in nature through rodent and avian hosts.

Funder

National Science Foundation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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