Affiliation:
1. Northern Marketing and Nutrition Research Division, Agricultural Research Service, U.S. Department of Agriculture, Peoria, Illinois 61604
2. National Animal Disease Laboratory, Veterinary Sciences Research Division, U.S. Department of Agriculture, Ames, Iowa 50010
Abstract
Isolates of
Helminthosporium maydis
from blighted corn were tested for toxicity in mice, rats, swine, rabbits, microorganisms, and tissue culture. Extracts of grains, mycelia, and culture supernatant fluids killed mice on intraperitoneal (ip) injection, but were nontoxic on administration by mouth to swine. The toxin was partially purified and appears to be a glycophospholipid. Histopathological examination revealed that the toxin acted as a severe irritant on ip injection, causing death in laboratory animals. In skin tests with rabbits, considerable exudation occurred, rather than necrosis.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
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