Nonionic block polymer surfactants enhance immunogenicity of pneumococcal hexasaccharide-protein vaccines-Reference-Cited by-同舟云学术

Nonionic block polymer surfactants enhance immunogenicity of pneumococcal hexasaccharide-protein vaccines

Published:1988-05 Issue:5 Volume:56 Page:1391-1393
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Zigterman G J¹,Snippe H¹,Jansze M¹,Ernste E B¹,De Reuver M J¹,Willers J M¹

Affiliation:

1. Department of Immunology, State University of Utrecht, The Netherlands.

Abstract

Incorporated in oil-in-water emulsions, nonionic block polymer surfactants change the kinetics of generated antibody responses against pneumococcal hexasaccharide-protein conjugates: prolonged immunoglobulin M and immunoglobulin G responses are realized. Nonionic block polymer surfactants favor the immunogenicity of hexasaccharide-protein conjugates in young mice in such a way that a single injection yields long-lasting protection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.56.5.1391-1393.1988

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