Intranasal Administration of HIV-DNA Vaccine Formulated with a Polymer, Carboxymethylcellulose, Augments Mucosal Antibody Production and Cell-Mediated Immune Response

Author:

Hamajima Kenji,Sasaki Shin,Fukushima Jun,Kaneko Tamiko,Xin Ke-Qin,Kudoh Ichidai,Okuda Kenji

Publisher

Elsevier BV

Subject

Immunology,Pathology and Forensic Medicine,Immunology and Allergy

Reference36 articles.

1. Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate;Bukawa;Nat. Med.,1996

2. Systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10MN(A);Staats;J. Immunol.,1996

3. Intranasal immunization of a DNA vaccine with IL-12 and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell mediated immune responses against HIV-1 antigens;Okada;J. Immunol.,1997

4. Intraperitoneal immunization of human subjects with tetanus toxoid induces specific antibody-secreting cells in the peritoneal cavity and in the circulation, but fails to elicit secretory IgA responses;Lue;Clin. Exp. Immunol.,1994

5. Induction of mucosal and systemic immunity to a recombinant simian immunodeficiency viral protein;Lehner;Science,1992

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