Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner-Reference-Cited by-同舟云学术

Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhong Zhou¹²,Ning Jiying³²,Boggs Emerson A.¹²,Jang Sooin²⁴⁵,Wallace Callen⁶²,Telmer Cheryl⁷,Bruchez Marcel P.⁷,Ahn Jinwoo³²,Engelman Alan N.²⁴⁵,Zhang Peijun³²⁸⁹,Watkins Simon C.⁶²,Ambrose Zandrea¹²^ORCID

Affiliation:

1. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

2. Pittsburgh Center for HIV Protein Interactions, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

3. Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

4. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

5. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

6. Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

7. Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

8. Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England

9. Electron Bio-Imaging Centre, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, United Kingdom

Abstract

HIV is the causative agent of AIDS, which has no cure. The protein shell that encases the viral genome, the capsid, is critical for HIV replication in cells at multiple steps.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

UK Wellcome Trust

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03142-20

Reference64 articles.

1. Assembly and Analysis of Conical Models for the HIV-1 Core