Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection-Reference-Cited by-同舟云学术

Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Xu Man¹^ORCID,Perdomo Maria Fernanda¹^ORCID,Mattola Salla²³,Pyöriä Lari¹^ORCID,Toppinen Mari¹^ORCID,Qiu Jianming⁴^ORCID,Vihinen-Ranta Maija²³^ORCID,Hedman Klaus¹⁵^ORCID,Nokso-Koivisto Johanna⁶⁷,Aaltonen Leena-Maija⁶⁷,Söderlund-Venermo Maria¹^ORCID

Affiliation:

1. Department of Virology, University of Helsinki, Helsinki, Finland

2. Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland

3. Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland

4. Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA

5. Helsinki University Hospital, Helsinki, Finland

6. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland

7. University of Helsinki, Helsinki, Finland

Abstract

Human bocavirus 1 (HBoV1), a common pediatric respiratory pathogen, can persist in airway secretions for months hampering diagnosis. It also persists in tonsils, providing potential reservoirs for airway shedding, with the exact location, host cell types, and virus activity unknown.

Funder

China Scholarship Council

the Finnish-Norwegian Medical Foundation

the Life and Health Medical Support Association

Helsinki University Hospital Research Funds

the Graduate School of the University of Jyvaskyla

European Union's Horizon 2020 research and innovation programme

project CoCID

Sigrid Juséliuksen Säätiö

Jane ja Aatos Erkon Säätiö

Academy of Finland

Suomen Kulttuurirahasto