SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators-Reference-Cited by-同舟云学术

SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Honrubia Jose M.¹,Gutierrez-Álvarez Javier¹,Sanz-Bravo Alejandro¹,González-Miranda Ezequiel¹,Muñoz-Santos Diego¹,Castaño-Rodriguez Carlos¹,Wang Li¹,Villarejo-Torres Marta¹,Ripoll-Gómez Jorge¹,Esteban Ana¹,Fernandez-Delgado Raul²,Sánchez-Cordón Pedro José³,Oliveros Juan Carlos⁴,Perlman Stanley⁵⁶⁷^ORCID,McCray Paul B.⁶⁸⁹,Sola Isabel¹,Enjuanes Luis¹^ORCID

Affiliation:

1. Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain

2. Department of Infectious Diseases and Global Health, Animal Health Research Center (CISA), National Institute of Research, Agricultural and Food Technology (INIA-CSIC), Valdeolmos, Madrid, Spain

3. Veterinary Pathology Department, Animal Health Research Center (CISA), National Institute of Research, Agricultural and Food Technology (INIA-CSIC), Valdeolmos, Madrid, Spain

4. Bioinformatics for Genomics and Proteomics Unit, CNB-CSIC, Campus Universidad Autónoma de Madrid, Madrid, Spain

5. Department of Microbiology, University of Iowa, Iowa City, USA

6. Stead Family Department of Pediatrics, The University of Iowa, Iowa City, Iowa, USA

7. Interdisciplinary Program in Immunology, University of Iowa, Iowa City, USA

8. Pappajohn Biomedical Institute, The University of Iowa, Iowa City, Iowa, USA

9. Center for Gene Therapy, The University of Iowa, Iowa City, Iowa, USA

Abstract

Three highly pathogenic human CoVs have been identified: SARS-CoV, MERS-CoV, and SARS-CoV-2. The E protein PBMs of these three CoVs were virulence factors.

Funder

Comunidad de Madrid

European Commission

Foundation for the National Institutes of Health

MEC | Consejo Superior de Investigaciones Científicas

MEC | Spanish National Plan for Scientific and Technical Research and Innovation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03136-22