Novel Biological Functions of the NsdC Transcription Factor in Aspergillus fumigatus

Author:

Alves de Castro Patrícia1,Valero Clara1,Chiaratto Jéssica1,Colabardini Ana Cristina12,Pardeshi Lakhansing23,Pereira Silva Lilian1,Almeida Fausto4ORCID,Campos Rocha Marina5,Nascimento Silva Roberto4,Malavazi Iran5ORCID,Du Wenyue6,Dyer Paul S.6,Brock Matthias6,Vieira Loures Flávio7,Wong Koon Ho28,Goldman Gustavo H.1ORCID

Affiliation:

1. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil

2. Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China

3. Genomics and Bioinformatics Core, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China

4. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil

5. Departamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, São Paulo, Brazil

6. Fungal Genetics and Biology Group, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

7. Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, São José dos Campos, Brazil

8. Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China

Abstract

Aspergillus fumigatus is an opportunistic human fungal pathogen and the main causal agent of invasive aspergillosis, a life-threatening infection especially in immunocompromised patients. A. fumigatus can undergo both asexual and sexual reproductive cycles, and the regulation of both cycles involves several genes and pathways. Here, we have characterized one of these genetic determinants, the NsdC transcription factor, which was initially identified in a screen of transcription factor null mutants showing sensitivity when exposed to high concentrations of calcium.

Funder

University of Macau

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

UKRI | Natural Environment Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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