Vaccination with Live or Heat-Killed Aspergillus fumigatus Δ <i>sglA</i> Conidia Fully Protects Immunocompromised Mice from Invasive Aspergillosis-Reference-Cited by-同舟云学术

Vaccination with Live or Heat-Killed Aspergillus fumigatus Δ sglA Conidia Fully Protects Immunocompromised Mice from Invasive Aspergillosis

Published:2022-10-26 Issue:5 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Fernandes Caroline Mota¹,Normile Tyler G.¹,Fabri Joao Henrique Tadini Marilhano²,Brauer Veronica Soares¹,de S. Araújo Glauber R.³,Frases Susana³,Nimrichter Leonardo⁴^ORCID,Malavazi Iran²^ORCID,Del Poeta Maurizio¹⁵⁶^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA

2. Departamento de Genética e Evolução, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Carlos, Brazil

3. Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

4. Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

5. Division of Infectious Diseases, School of Medicine, Stony Brook University, Stony Brook, New York, USA

6. Veterans Administration Medical Center, Northport, New York, USA

Abstract

Infections by Aspergillus fumigatus occur by the inhalation of environmental fungal spores called conidia. We found that live mutant conidia accumulating glycolipids named sterylglucosides are not able to cause disease when injected into the lung.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Veterans Administration Medical Center

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02328-22

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