Pharmacokinetics of a single dose of rimantadine in young adults and children-Reference-Cited by-同舟云学术

Pharmacokinetics of a single dose of rimantadine in young adults and children

Published:1987-07 Issue:7 Volume:31 Page:1140-1142
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Anderson E L¹,Van Voris L P¹,Bartram J¹,Hoffman H E¹,Belshe R B¹

Affiliation:

1. Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701.

Abstract

Single doses of rimantadine were given to children and young adults to evaluate the safety and pharmacokinetics of this antiviral compound. The half-life of rimantadine in young adults was 27.7 +/- 4.9 h for tablets and 27.8 +/- 8.0 h for syrup preparations. A total of 10 children, 5 to 8 years old, received a syrup preparation of rimantadine. The half-life of rimantadine in children was 24.8 +/- 9.4 h. A single dose of rimantadine was well tolerated in young adults and children.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.31.7.1140

Reference5 articles.

1. Influenza A in children. Relationship to other respiratory agents;Glezen W. P.;J. Am. Med. Assoc.,1980

2. Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults;Hayden F.;Antimicrob. Agents Chemother,1981

3. Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics;Hayden F. G.;Antimicrob. Agents Chemother.,1983

4. Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults;Hayden F. G.;Antimicrob. Agents Chemother.,1985

5. Impact of type A influenza on children: a retrospective study;Mullooly J. P.;Am. J. Public Health,1982

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