Apical Gene Transfer into Quiescent Human and Canine Polarized Intestinal Epithelial Cells by Lentivirus Vectors-Reference-Cited by-同舟云学术

Apical Gene Transfer into Quiescent Human and Canine Polarized Intestinal Epithelial Cells by Lentivirus Vectors

Published:2000-08-15 Issue:16 Volume:74 Page:7642-7645
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Seppen Jurgen¹,Barry Simon C.¹,Klinkspoor J. Henriette²,Katen Louis J.¹,Lee Sum P.²³,Garcia J. Victor⁴,Osborne William R. A.¹

Affiliation:

1. Department of Pediatrics, School of Medicine,1 and

2. Department of Gastroenterology,2 University of Washington, and

3. Veterans Affairs Medical Center,3 Seattle, Washington, and

4. Department of Internal Medicine, Southwestern Medical Center, Dallas, Texas4

Abstract

ABSTRACT Intestinal epithelial cells secrete a protective luminal mucus barrier inhibiting viral gene transfer. Quiescent, polarized monolayers of primary epithelial cells from dog gallbladder and human colon are efficiently transduced through the apical mucus side by lentivirus vectors, suggesting their application to intestinal gene therapy.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.16.7642-7645.2000

Reference18 articles.

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2. Transduction of Well-Differentiated Airway Epithelium by Recombinant Adeno-Associated Virus Is Limited by Vector Entry

3. Efficient transduction of human lymphocytes and CD34+ cells via human immunodeficiency virus-based gene transfer vectors;Douglas J.;Hum. Gene Ther.,1999

4. A Third-Generation Lentivirus Vector with a Conditional Packaging System

5. Gastrointestinal manifestations in cystic fibrosis;Eggermont E.;Gastroenterol. Hepatol.,1996

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