Diminished Macrophage Inflammatory Response to Staphylococcus aureus Isolates Exposed to Daptomycin versus Vancomycin or Oxacillin-Reference-Cited by-同舟云学术

Diminished Macrophage Inflammatory Response to Staphylococcus aureus Isolates Exposed to Daptomycin versus Vancomycin or Oxacillin

Published:2006-06 Issue:6 Volume:50 Page:2225-2227
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

English B. Keith¹²,Maryniw Erik M.²,Talati Ajay J.¹³²,Meals Elizabeth A.¹²

Affiliation:

1. Departments of Pediatrics

2. Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee 38103

3. Obstetrics-Gynecology, University of Tennessee Health Science Center

Abstract

ABSTRACT Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nitric oxide synthase protein.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01559-05

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