Daptomycin disrupts membrane potential in growing Staphylococcus aureus-Reference-Cited by-同舟云学术

Daptomycin disrupts membrane potential in growing Staphylococcus aureus

Published:1991-11 Issue:11 Volume:35 Page:2282-2287
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alborn W E¹,Allen N E¹,Preston D A¹

Affiliation:

1. Infectious Disease Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.

Abstract

Daptomycin (LY146032) caused a calcium-dependent dissipation of the membrane potential (delta psi) in Staphylococcus aureus without noticeably affecting the chemical gradient (delta pH) across the membrane. The effect of daptomycin on membrane energization may account for many of the inhibitory effects on macromolecular biosyntheses and membrane function reported for this antibiotic. Our evidence indicates that the bactericidal activity of daptomycin is dependent on an available delta psi.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.35.11.2282

Reference21 articles.

1. The use of valinomycin, nigericin, and trichlorocarbanilide in control of the protonmotive force in Escherichia coli cells;Ahmed S.;Biochem. J.,1983

2. Alborn W. E. Jr. Unpublished data.

3. Alborn W. E. Jr. N. E. Allen J. E. Flokowitsch and D. A. Preston. 1990. Daptomycin has an effect upon the electrical potential of growing cells of Staphylococcus aureus abstr. 839 p. 226. Program Abstr. 30th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology Washington D.C.

4. Allen N. W. Alborn Jr. J. Hobbs Jr. and H. Percifield. 1984. LY146032 inhibits the biosynthesis of cell wall peptidoglycan in gram-positive bacteria abstr. 1081 p. 281. Program Abstr. 24th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology Washington D.C.

5. Allen N. E. W. E. Alborn Jr. and J. N. Hobbs Jr. Submitted for publication.

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