Human Herpesvirus 6 Latently Infects Early Bone Marrow Progenitors In Vivo-Reference-Cited by-同舟云学术

Human Herpesvirus 6 Latently Infects Early Bone Marrow Progenitors In Vivo

Published:1999-01 Issue:1 Volume:73 Page:754-759
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Luppi Mario¹,Barozzi Patrizia¹,Morris Christine²,Maiorana Antonio³,Garber Richard⁴,Bonacorsi Goretta¹,Donelli Amedea¹,Marasca Roberto¹,Tabilio Antonio⁵,Torelli Giuseppe¹

Affiliation:

1. Section of Hematology, Department of Medical Sciences,1 and

2. Cytogenetic and Molecular Oncology Unit, Department of Pathology, Christchurch School of Medicine, Christchurch, New Zealand2; and

3. Department of Pathology,3 University of Modena, Modena, and

4. PathoGenesis Corporation, Seattle, Washington4

5. Clinical Hematology and Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia,5 Italy;

Abstract

ABSTRACT We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.1.754-759.1999

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