Role of Inducible Nitric Oxide Synthase in Resistance to Mycobacterium leprae in Mice-Reference-Cited by-同舟云学术

Role of Inducible Nitric Oxide Synthase in Resistance to Mycobacterium leprae in Mice

Published:2000-09 Issue:9 Volume:68 Page:5462-5465
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Adams Linda B.¹,Job Charles K.²,Krahenbuhl James L.¹

Affiliation:

1. National Hansen's Disease Programs, Laboratory Research Branch at Louisiana State University, Baton Rouge, Louisiana,1 and

2. St. Thomas Hospital and Leprosy Centre, Chettupattu TS Dt 606 801 Tamil Nadu, South India2

Abstract

ABSTRACT The manifestation of leprosy in humans is largely determined by host immunity to Mycobacterium leprae and is a model for immunoregulation in a human disease. However, animal models available for exploration of the leprosy spectrum are inadequate. This study explored M. leprae infection in mice deficient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.9.5462-5465.2000

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