PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand

Author:

Ishizuka Shigenari12,van Dijk J. Hessel M.3,Kawakita Tomomi4,Miyamoto Yuji4,Maeda Yumi4,Goto Masamichi5,Le Calvez Guillaume6,Groot L. Melanie3,Witte Martin D.6ORCID,Minnaard Adriaan J.6ORCID,van der Marel Gijsbert A.3,Ato Manabu4,Nagae Masamichi12,Codée Jeroen D. C.3ORCID,Yamasaki Sho127

Affiliation:

1. Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan

2. Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan

3. Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

4. Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aobacho, Higashimurayama, Tokyo 189-0002, Japan

5. Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

6. Stratingh Institute for Chemistry, Nijenborgh 7, 9747 AG Groningen, The Netherlands

7. Center for Infectious Disease Education and Research, Osaka University (CiDER), 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan

Funder

Core Research for Evolutional Science and Technology

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Reference46 articles.

1. Leprosy

2. W.H.O. Leprosy hansen disease: management of reactions and prevention of disabilities: technical guidance; 2020.

3. The Mycobacterial Cell Envelope--Lipids

4. Immune Response to Mycobacterium tuberculosis: A Narrative Review

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