Improved Tolerability of a Salmonella enterica Serovar Typhimurium Live-Attenuated Vaccine Strain Achieved by Balancing Inflammatory Potential with Immunogenicity-Reference-Cited by-同舟云学术

Improved Tolerability of a Salmonella enterica Serovar Typhimurium Live-Attenuated Vaccine Strain Achieved by Balancing Inflammatory Potential with Immunogenicity

Published:2018-12 Issue:12 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Higginson Ellen E.¹²,Ramachandran Girish¹²,Panda Aruna³⁴⁵,Shipley Steven T.³⁴,Kriel Edwin H.³⁴,DeTolla Louis J.²³⁴⁵,Lipsky Michael⁴,Perkins Darren J.⁶,Salerno-Goncalves Rosangela¹⁷,Sztein Marcelo B.¹⁷,Pasetti Marcela F.¹⁷,Levine Myron M.¹²⁷,Tennant Sharon M.¹²

Affiliation:

1. Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA

2. Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA

3. Program of Comparative Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA

4. Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA

5. Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA

6. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA

7. Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA

Abstract

A notable proportion of Salmonella -associated gastroenteritis in the United States is attributed to Salmonella enterica serovar Typhimurium. We have previously shown that live-attenuated S .

Funder

HHS | National Institutes of Health

National Aeronautics and Space Administration

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00440-18

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